Analysis outcomes have been mixed, some saying Lysine is helpful in reducing and therapeutic cold sores, different studies saying that it does not really scale back the recurrence or severity of cold sore outbreaks.

The exception to the rule is the DOT1 family, members of which methylate K79 in the globular region of histone H3 and which are structurally not associated to SET-domain proteins 4 - 6 Recent work means that SET-area-containing proteins methylate a couple of proteins along with histones (see later)